Disable Notification Center on Mountain Lion

This is the preferred method:

  1. Open Terminal and enter the following command:
    launchctl unload -w /System/Library/LaunchAgents/com.apple.notificationcenterui.plist
  2. Next type the following command to kill NotificationCenter:
    killall NotificationCenter
  3. Finally, quit out of Terminal and return to Finder

This unloads Notification Center for the current user only and does not require admin access. To re-enable Notifications with this approach:

  1. Launch Terminal and enter a similar command – notice load instead of unload:
    launchctl load -w /System/Library/LaunchAgents/com.apple.notificationcenterui.plist
  2. Hit Command+Shift+G and go to /System/Library/CoreServices/ then find “Notification Center” and double-click it to launch it again

This is the older approach that is less preferred, but it does work in OS X Mountain Lion:

  1. From the OS X Finder, hit Command+Shift+G and enter the path to /System/Library/CoreServices/
  2. Locate “Notification Center.app” and click on the name to rename it to “Notification Center-disabled.app”, authenticate the change when prompted
  3. Now launch Terminal, found in /Applications/Utilities/ and type the following command:
        killall NotificationCenter
  4. Quit out of Terminal